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Matrixyl 3000® : The Ultimate Solution for Menopausal Skin

Matrixyl 3000® is a peptide-based product that enhances collagen production, supports skin repair, and reduces fine lines and wrinkles. Especially beneficial for perimenopausal, menopausal, and postmenopausal skin, Matrixyl 3000® combines...

The beauty industry is constantly evolving, creating new products and developing improved formulations. Matrixyl 3000® is one of our favourites due to its effectiveness. What makes Matrixyl 3000® so significant, and why is it considered one of the most important ingredients in products targeting perimenopausal, menopausal, and postmenopausal skin along with associated anti-ageing concerns?

Matrixyl 3000® is a registered product by Sederma (Croda International). It is a peptide-based ingredient that effectively supports overall skin health and reduces signs of ageing, including fine lines and wrinkles. This ingredient is also an excellent option for people with sensitive skin, which is often a concern during perimenopause, menopause, and postmenopause. Matrixyl 3000® contains matrikines, peptides that facilitate skin repair and restructuring. The skin requires peptides (short chains of amino acids), and this supplement is made of minute protein particles that mirror the skin’s natural peptides and enhance the formation of collagen.

In Matrixyl 3000®, there are two main peptides:

- Palmitoyl Tripeptide-1

- Palmitoyl Tetrapeptide-7

Both peptides combine to nourish the skin and reverse the ageing process at the molecular level. Studies have shown that using Matrixyl 3000® for just two months reduced the area of deep wrinkles on the face by 45%.

Another benefit of Matrixyl 3000® in skincare is its ability to prevent and reverse glycation, which contributes to premature ageing and compromises collagen’s ability to keep the skin firm. This is particularly beneficial for perimenopausal, menopausal, and postmenopausal women who often experience accelerated skin ageing.

Peptides are tiny protein fragments formed when amino acids join together. For example, when two amino acids connect, they form a dipeptide; three amino acids in a chain are called a tripeptide, etc. While all proteins consist of linked amino acids, peptides and proteins differ in size. Peptides contain 2 to 50 amino acids, while proteins are made up of 50 or more amino acids. Peptides may be subdivided into oligopeptides (2 to 20 amino acids) and polypeptides (20 to 50 amino acids). Proteins, on the other hand, are formed from one or more polypeptides combined together, making them essentially very large peptides. Due to their small size, peptides can penetrate the cell barrier and be absorbed by our tissues.

Peptides are naturally produced in our bodies using extracellular matrix (ECM) proteins such as collagen, elastin, fibronectin, and antimicrobial peptide (AMP) precursor proteins. Peptides created from the partial proteolysis (breakdown) of ECM proteins are known as matrikines. Matrikines help maintain cell equilibrium by aiding in cell signalling.

The application of Matrixyl 3000® is quite unique to skincare, and it has justifiably established a reputation as a potent anti-ageing tool. Choi et al. (2014) conducted scientific research that proved this ingredient's potential to reduce wrinkles and irregularities, improving skin tone with proper usage.

Matrixyl 3000® – A Scientific Review

Peptide molecules, made of short chains of amino acids, are significant in making proteins like collagen and elastin. These proteins are vital for reinforcing skin tissues and skin elasticity. Matrixyl 3000® increases collagen synthesis, firms the skin, and reduces wrinkles. Matrixyl 3000® combines palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, creating a powerful duo that promotes a younger appearance. This makes Matrixyl 3000® one of the most powerful synthetic peptides used in skincare.

  • Palmitoyl Tripeptide-1 (Pal-GHK): This peptide replicates the natural sequences of collagen, boosting collagen production in the skin. As a result, it helps reduce fine lines and wrinkles, making the skin firmer and smoother.

  • Palmitoyl Tetrapeptide-7 (Pal-GQPR): It synthesises proteins that minimise inflammation and glycation. Glycation occurs when sugar binds with proteins like collagen to form AGEs that harm collagen and elastin. Palmitoyl tetrapeptide-7 helps maintain the structural integrity of the skin by preventing and reversing glycation. It reduces skin redness and inflammation, stimulates collagen production, relaxes muscles to minimise wrinkles, and synergises with palmitoyl tripeptide-1 to catalyse robust collagen synthesis.

The Benefits of Matrixyl 3000®

Matrixyl 3000® is skin-safe and highly acclaimed in anti-ageing skincare. It's proven non-irritating with minimal side effects, making it ideal for diverse skin types, including sensitive skin. This makes it especially suitable for perimenopausal, menopausal, and postmenopausal skin, which can be more prone to irritation and sensitivity. Some benefits of Matrixyl 3000® are:

1. Boosts Collagen Production

Matrixyl 3000® significantly enhances collagen production, vital for maintaining skin elasticity and firmness. As we age, collagen levels drop, causing sagging skin and wrinkles. By stimulating collagen synthesis, Matrixyl 3000® helps restore a youthful appearance.

2. Enhanced Skin Repair

The peptides in Matrixyl 3000® support skin repair and regeneration. They fortify the skin’s barrier function, increasing resilience to environmental damage and stress. This leads to healthier, more radiant skin, which is particularly beneficial during the hormonal changes of perimenopause, menopause, and postmenopause.

3. Moisture Retention

Matrixyl 3000® enhances moisture retention in the skin, promoting a plumper and more radiant complexion by aiding in maintaining hydration.

4. Clearer Complexion and Elasticity

Matrixyl 3000®, when used regularly, improves skin tone and elasticity. Increased collagen and elastin production firms the skin, providing a more youthful appearance.

5. Diminished Fine Lines and Wrinkles

Clinical studies indicated that Matrixyl 3000® significantly reduces wrinkles and fine lines. It increases collagen production, improving skin texture and smoothing wrinkles, giving a more youthful plump look.

6. Anti-Inflammatory Properties

Matrixyl 3000®, containing palmitoyl tetrapeptide-7, has anti-inflammatory properties that soothe and calm the skin, reducing redness and irritation—both triggers for accelerated skin ageing. This is especially helpful for women undergoing menopause, who may experience increased skin sensitivity and inflammation.

7. Antioxidant Properties

Matrixyl 3000® has antioxidant components that protect the skin from harm caused by free radicals. These unstable particles contribute to ageing and skin damage. Matrixyl 3000® counters the synthesis of these damaged peptides, protecting skin health and youth.

8. Safe for All Skin Types

Matrixyl 3000® is compatible with all skin types, including sensitive skin, with a low likelihood of causing irritation or side effects, making it suitable for women at various stages of menopause.

Healthy Menopausal Woman

How Matrixyl 3000® Functions

Matrixyl 3000® works with the skin’s natural repair mechanisms. The topical application of Matrixyl 3000® triggers fibroblasts to produce collagen and elastin. It also stimulates the skin’s innate healing processes, leading to increased collagen deposits and skin architecture improvement. Additionally, Matrixyl 3000® interferes with glycation, maintaining the function of newly formed collagen and elastin. This two-pronged approach makes Matrixyl 3000® very effective in addressing the signs of ageing.

Matrixyl 3000® has proven its effectiveness in decreasing fine lines and wrinkles, increasing skin firmness, and improving skin tone and texture. It is statistically evidenced to work and is widely used in anti-ageing skincare products.

Findings from Clinical Studies/Trials

Matrixyl 3000® is a peptide compound widely used in cosmetic products with anti-ageing effects. Its efficacy is supported by scientific evidence. Key findings from clinical studies and trials on Matrixyl 3000® include:

  • One study showed that Matrixyl 3000® effectively minimises expression lines and visible pores. The peptide complex enhances collagen synthesis and skin elasticity over several weeks (Sanders, 2023).

  • In another clinical trial, a Matrixyl 3000® treatment improved skin tone and firmness compared to a placebo, indicating the ingredient’s effectiveness in combating ageing (Aldag et al., 2016).

  • A study assessed the effects of Matrixyl 3000® on wrinkle depth and volume over time. Continuous use of Matrixyl 3000® significantly diminished wrinkle depth and volume, making it a potent anti-ageing agent (Li et al., 2023).

These studies highlight that Matrixyl 3000® enhances collagen synthesis and skin firmness in anti-ageing cosmetic products.

Patch Testing

Before incorporating Matrixyl 3000® into a daily skincare routine, it's essential to perform a patch test to check for any adverse reactions. Apply a drop of the product behind the ear or on the inner forearm and check for any signs of irritation after two to three days.


Matrixyl 3000® is one of the most effective anti-ageing ingredients, supported by extensive experimental evidence and robust clinical trials. The combination of peptides—palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7—stimulates collagen synthesis, decreases inflammation, and improves the skin repair process. Matrixyl 3000® enhances skin complexion, tonality, and elasticity, significantly reducing fine lines and wrinkles. It is safe for all skin types, making it a versatile ingredient widely used in luxury beauty products. As the beauty industry evolves, Matrixyl 3000® remains an unparalleled product for achieving youthful, radiant skin with scientifically tested ingredients. Its suitability for perimenopausal, menopausal, and postmenopausal skin further underscores its importance in addressing the specific skin care needs of women during these stages.


Aldag, C., Teixeira, D. N., & Leventhal, P. S. (2016). Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: A review of the literature. Clinical, Cosmetic and Investigational Dermatology, Volume 9, 411–419.

Choi, Y. L., Park, E. J., Kim, E., Na, D. H., & Shin, Y.-H. (2014). Dermal stability and in vitro skin permeation of collagen pentapeptides (KTTKS and Palmitoyl-KTTKS). Biomolecules & Therapeutics, 22(4), 321–327.

Li, F., Chen, H., Chen, D., Zhang, B., Shi, Q., He, X., Zhao, H., & Wang, F. (2023). Clinical evidence of the efficacy and safety of a new multi‐peptide anti‐aging topical eye serum. Journal of Cosmetic Dermatology, 22(12), 3340–3346.

Sanders, K. (2023). Unveiling the power of Matrixyl in Skincare. Reviva Labs.


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